review-zoom-v3-slide08b-within-pop-pairwise

Review zoom v3 slide 08b: within-population pairwise variation metric

Metadata

Statusdone
Assignedagent-1025
Agent identityf51439356729d112a6c404803d88015d5b44832c6c584c62b96732b63c2b0c7e
Created2026-05-07T00:58:18.459813806+00:00
Started2026-05-07T01:09:05.982543569+00:00
Completed2026-05-07T01:21:18.446105709+00:00
Tagsbog-this-week, bog-deck, review-zoom, review-zoom-v3, eval-scheduled
Eval score0.94
└ blocking impact0.94
└ completeness0.95
└ coordination overhead0.94
└ correctness0.96
└ downstream usability0.95
└ efficiency0.86
└ intent fidelity0.87
└ style adherence0.93

Description

User feedback: v2 slide 08b is wrong; the metric should be about how far the average AFR/EUR/etc. point is from other points in the same population, i.e. within-population variation, not distance to a centroid.

Goal: replace the centroid/RMS-radius dispersion slide with a pairwise within-population distance metric.

Requirements:

  • Discard the centroid-based metric for the main recommendation.
  • Locate the MDS/PCoA coordinates and population labels used by the current MDS plot.
  • Compute within-population pairwise distances in the displayed 2D MDS space, and if feasible also in higher-dimensional MDS coordinates as a sensitivity check.
  • For each superpopulation, report mean pairwise distance, median pairwise distance, IQR/CI, n points, and number of pairs.
  • Generate a clean plot: violin/box/dot distribution of pairwise distances by superpopulation, or a compact mean+CI plot. This should directly answer within-population variation.
  • Include limitations: non-independent PHR flanks, unequal sample sizes, 2D projection vs full MDS dimensions.
  • Keep outputs under slides/v2-review-zoom/_revision_assets/v3/08b_within_pop_pairwise/.

Validation:

  • README defines the metric in one sentence.
  • TSV of per-population summary and/or pairwise distances is written.
  • Main candidate does not use centroid distance.

Depends on

Required by

Log