← graph

validate-weighted-phyper

Validate weighted phyper() statistical properties

Metadata

Statusdone
Assignedagent-130
Agent identity3184716484e6f0ea08bb13539daf07686ee79d440505f1fdf2de0357707034c3
Created2026-04-01T15:01:07.307681898+00:00
Started2026-04-01T15:06:37.461528779+00:00
Completed2026-04-01T15:18:39.261917414+00:00
Tagseval-scheduled
Eval score0.53
└ blocking impact0.55
└ completeness0.40
└ coordination overhead0.40
└ correctness0.60
└ downstream usability0.45
└ efficiency0.50
└ intent fidelity0.55
└ style adherence0.75

Description

Validate that copy-number weighted phyper() modifications preserve correct statistical properties of the hypergeometric distribution. Test null distributions, Type I error rates, and power characteristics.

Statistical Validations:

  1. Null distribution validation (uniform p-values under null)
  2. Type I error rate control (alpha = 0.05)
  3. Power analysis vs standard approaches
  4. Multiple testing correction behavior

Test Scenarios:

  • Random gene sets (null hypothesis)
  • Known enriched pathways (positive controls)
  • Copy-number stratified analyses
  • Different background models

Statistical Tests:

  • Kolmogorov-Smirnov tests for uniformity
  • Simulation-based validation studies
  • ROC analysis for power comparison
  • FDR correction validation

Expected Outputs:

  • Statistical validation report
  • Simulation study results
  • Recommendations for statistical best practices

Depends on

Required by

Log