research-neuron-projection

Metadata

Status	done
Assigned	`agent-44`
Agent identity	`3184716484e6f0ea08bb13539daf07686ee79d440505f1fdf2de0357707034c3`
Created	2026-03-31T22:27:30.334095785+00:00
Started	2026-03-31T22:28:16.552634747+00:00
Completed	2026-03-31T22:31:00.077791614+00:00
Tags	`research,fan-out`, `eval-scheduled`
Eval score	0.96
└ blocking impact	1.00
└ completeness	1.00
└ coordination overhead	1.00
└ correctness	0.95
└ downstream usability	0.95
└ efficiency	0.90
└ intent fidelity	0.77
└ style adherence	0.95

Description

Goal

Briefly investigate the singleton GO term hit for neuron projection arborization.

Context

One borderline term appeared:

Negative regulation of neuron projection arborization (BP, p=0.016, 1/22 genes)

This is a single gene hitting a very small GO category (term_size=1).

Questions to answer

Which gene is this? Identify it.
Is this meaningful or a statistical artifact? A single gene matching a category of size 1 is likely noise — but confirm.
Brief assessment: 1-2 sentences on whether this should be mentioned in the paper or ignored.

Output

Log the gene name and a brief assessment (keep this short — this is likely noise).

Validation

Gene identified
Clear recommendation: include or exclude from paper narrative

## Goal
Briefly investigate the singleton GO term hit for neuron projection arborization.

## Context
One borderline term appeared:
- Negative regulation of neuron projection arborization (BP, p=0.016, 1/22 genes)

This is a single gene hitting a very small GO category (term_size=1). 

## Questions to answer
1. **Which gene is this?** Identify it.
2. **Is this meaningful or a statistical artifact?** A single gene matching a category of size 1 is likely noise — but confirm.
3. **Brief assessment**: 1-2 sentences on whether this should be mentioned in the paper or ignored.

## Output
Log the gene name and a brief assessment (keep this short — this is likely noise).

## Validation
- Gene identified
- Clear recommendation: include or exclude from paper narrative

Depends on

done .assign-research-neuron-projection

Required by

done synthesis-phr-gene

Log

2026-03-31T22:27:30.332505059+00:00 Task paused
2026-03-31T22:27:47.484731571+00:00 Task published
2026-03-31T22:28:16.552636219+00:00 Spawned by coordinator --executor claude --model claude-sonnet-4-20250514
2026-03-31T22:28:33.708483981+00:00 Starting investigation of neuron projection arborization GO term hit
2026-03-31T22:28:51.957970930+00:00 Found the GO term: GO:0150013 'negative regulation of neuron projection arborization' with p=0.0152, term_size=1, intersection_size=1
2026-03-31T22:29:14.584298549+00:00 Found g:Profiler query has 244 genes, but GO enrichment results show query_size=23. Need to identify which specific gene maps to GO:0150013
2026-03-31T22:30:06.592993892+00:00 Identified SPRY3 as the gene responsible for GO:0150013 hit. SPRY3 inhibits neurite branching and arborization - confirmed by literature.
2026-03-31T22:30:50.238474177+00:00 Validated: Gene identified (SPRY3), meaningful vs artifact assessed (meaningful), recommendation provided (include in paper)
2026-03-31T22:31:00.077795611+00:00 Task marked as done