or4f-disease-associations

Metadata

Status	done
Assigned	`agent-480`
Agent identity	`3184716484e6f0ea08bb13539daf07686ee79d440505f1fdf2de0357707034c3`
Created	2026-04-02T03:38:34.114071666+00:00
Started	2026-04-02T03:46:46.575959662+00:00
Completed	2026-04-02T03:48:59.002071179+00:00
Tags	`eval-scheduled`
Eval score	0.87
└ blocking impact	0.90
└ completeness	0.85
└ coordination overhead	0.95
└ correctness	0.90
└ downstream usability	0.90
└ efficiency	0.90
└ intent fidelity	0.88
└ style adherence	0.90

Description

Goal

Research disease associations of OR4F genes and CNV:

Any links between OR4F CNV and anosmia?
Connections to neurodegenerative disease?
Other medical conditions associated with OR4F variation?
Clinical genetics literature on OR gene disorders

Output

Summary of OR4F medical/disease associations. Save findings to or4f_disease_associations.md

Validation

Anosmia/smell disorder connections documented
Neurodegenerative disease links evaluated
Other medical associations reviewed
Clinical literature citations included

## Goal
Research disease associations of OR4F genes and CNV:
- Any links between OR4F CNV and anosmia?
- Connections to neurodegenerative disease?
- Other medical conditions associated with OR4F variation?
- Clinical genetics literature on OR gene disorders

## Output
Summary of OR4F medical/disease associations.
Save findings to or4f_disease_associations.md

## Validation
- Anosmia/smell disorder connections documented
- Neurodegenerative disease links evaluated
- Other medical associations reviewed
- Clinical literature citations included

Depends on

Required by

done integrate-or4f-deep

Log

2026-04-02T03:46:46.575961967+00:00 Spawned by coordinator --executor claude --model claude-sonnet-4-20250514
2026-04-02T03:47:00.328818051+00:00 Starting OR4F disease associations research
2026-04-02T03:47:54.374721206+00:00 Completed web research on OR4F disease associations. Found specific neurodegenerative connections for OR4F4, general OR CNV-anosmia links, and subtelomeric medical relevance. Now compiling findings.
2026-04-02T03:48:49.811096927+00:00 Validated: anosmia/smell disorder connections documented via CNV research; neurodegenerative disease links evaluated with specific OR4F4 findings; other medical associations reviewed including metabolic/immune/cancer; clinical literature citations included from 2025-2026 sources
2026-04-02T03:48:59.002074726+00:00 Task marked as done