multi-copy-or — workgraph

Metadata

Status	done
Assigned	`agent-462`
Agent identity	`3184716484e6f0ea08bb13539daf07686ee79d440505f1fdf2de0357707034c3`
Created	2026-04-02T03:38:28.852798152+00:00
Started	2026-04-02T03:39:52.863094344+00:00
Completed	2026-04-02T03:43:14.129416303+00:00
Tags	`eval-scheduled`
Eval score	0.91
└ blocking impact	0.90
└ completeness	0.92
└ coordination overhead	0.93
└ correctness	0.95
└ downstream usability	0.85
└ efficiency	0.88
└ intent fidelity	0.97
└ style adherence	0.90

Description

Goal

Research functional significance of multi-copy olfactory receptors:

Does having 20 copies of OR4F17 across chromosome arms mean anything functionally?
Can multiple OR copies be expressed simultaneously?
Are most copies silenced/pseudogenized?
Literature on multi-copy OR gene regulation and function

Output

Analysis of multi-copy OR functional implications. Save findings to multi_copy_or_significance.md

Validation

Multi-copy OR expression patterns documented
Silencing/pseudogenization mechanisms explained
Functional implications of copy number discussed
Literature citations included

## Goal
Research functional significance of multi-copy olfactory receptors:
- Does having 20 copies of OR4F17 across chromosome arms mean anything functionally?
- Can multiple OR copies be expressed simultaneously?
- Are most copies silenced/pseudogenized?
- Literature on multi-copy OR gene regulation and function

## Output
Analysis of multi-copy OR functional implications.
Save findings to multi_copy_or_significance.md

## Validation
- Multi-copy OR expression patterns documented
- Silencing/pseudogenization mechanisms explained
- Functional implications of copy number discussed
- Literature citations included

Depends on

Required by

done integrate-or4f-deep

Log

2026-04-02T03:39:52.863096718+00:00 Spawned by coordinator --executor claude --model claude-sonnet-4-20250514
2026-04-02T03:40:12.929120989+00:00 Starting research on multi-copy OR functional significance. Will investigate expression patterns, silencing mechanisms, and functional implications of OR4F gene copy number.
2026-04-02T03:40:33.909195650+00:00 Found extensive documentation of OR4F17 with 20 copies across 20 chromosome arms. Reviewing literature on multi-copy OR expression and functional significance.
2026-04-02T03:41:23.629684453+00:00 Beginning synthesis of multi-copy OR functional significance research. Found evidence of pseudogenes in PHRs and starting literature review on OR expression patterns.
2026-04-02T03:42:36.207801127+00:00 Validated: All task criteria met - (1) Multi-copy OR expression patterns documented with monoallelic principle and probability models, (2) Silencing mechanisms explained including chromatin silencing and pseudogenization, (3) Functional implications discussed including enhanced sensitivity and evolutionary advantages, (4) Literature citations included with 8 key references
2026-04-02T03:43:14.129424128+00:00 Task marked as done