Description
Description
Produce ED5 (4 panels) — Hi-C multi-resolution and confound-exclusion robustness. Implement directly — do not decompose further.
File scope
paper_prep/figures/ed5/figure_ed5.{pdf,png,R/py}, caption.md, sources.tsv
Figure spec (excerpt from MANUSCRIPT_SKELETON.md ED5)
ED5 — Multi-resolution + confound-exclusion robustness for Hi-C
| Panel | Content | Status | Source |
|---|
| ED5a | B/W ratio across 5 mcool resolutions (5/10/20/50/100 kb) for 8 datasets | GENERATE | community_based/{res}bp/<sample>_global_test.tsv × 8 — SURVEY_05 §6.1 Main 5B(a) |
| ED5b | Acrocentric / sex / strong-community exclusion grid — Mantel ρ before/after | GENERATE | no_acrocentric/{res}bp/<sample>_global_test.tsv — SURVEY_05 §6.2 SI 5.5 |
| ED5c | O/E-normalised within vs between contact (8.6–34.4× separation) | GENERATE | *_oe_matrix.tsv — SURVEY_05 §1.10 |
| ED5d | Per-community reproducibility heatmap (15 communities × 10 datasets; * = q < 0.05) | GENERATE | *_community_bootstrap_tests.tsv — SURVEY_05 §6.2 SI 5.8 |
Validation
-
All 4 panels; sources.tsv complete
-
Caption ≤ 200 words; ≥ 2 metrics with TSV paths
-
PDF + PNG
Inputs
paper_prep/synthesis/MANUSCRIPT_SKELETON.mdpaper_prep/surveys/SURVEY_05_hic_validation.md
## Description
Produce ED5 (4 panels) — Hi-C multi-resolution and confound-exclusion robustness. Implement directly — do not decompose further.
## File scope
- `paper_prep/figures/ed5/figure_ed5.{pdf,png,R/py}`, `caption.md`, `sources.tsv`
## Figure spec (excerpt from MANUSCRIPT_SKELETON.md ED5)
### ED5 — Multi-resolution + confound-exclusion robustness for Hi-C
| Panel | Content | Status | Source |
|---|---|---|---|
| ED5a | B/W ratio across 5 mcool resolutions (5/10/20/50/100 kb) for 8 datasets | GENERATE | `community_based/{res}bp/<sample>_global_test.tsv` × 8 — `SURVEY_05 §6.1 Main 5B(a)` |
| ED5b | Acrocentric / sex / strong-community exclusion grid — Mantel ρ before/after | GENERATE | `no_acrocentric/{res}bp/<sample>_global_test.tsv` — `SURVEY_05 §6.2 SI 5.5` |
| ED5c | O/E-normalised within vs between contact (8.6–34.4× separation) | GENERATE | `*_oe_matrix.tsv` — `SURVEY_05 §1.10` |
| ED5d | Per-community reproducibility heatmap (15 communities × 10 datasets; * = q < 0.05) | GENERATE | `*_community_bootstrap_tests.tsv` — `SURVEY_05 §6.2 SI 5.8` |
## Validation
- [ ] All 4 panels; sources.tsv complete
- [ ] Caption ≤ 200 words; ≥ 2 metrics with TSV paths
- [ ] PDF + PNG
## Inputs
- `paper_prep/synthesis/MANUSCRIPT_SKELETON.md`
- `paper_prep/surveys/SURVEY_05_hic_validation.md`
Log
- 2026-05-05T05:37:32.616226371+00:00 Lightweight assignment: agent=Careful Programmer (f5143935), exec_mode=full, context_scope=task, reason=Careful Programmer is best fit: proven implementation track record (83 tasks, 0.83 score), 'Careful' tradeoff ensures scientific accuracy in data visualization, and programming expertise covers multi-panel figure generation and TSV processing.
- 2026-05-05T05:41:44.467908597+00:00 Spawned by coordinator --executor claude --model opus
- 2026-05-05T05:41:55.714602223+00:00 Starting ED5 implementation: 4 panels — Hi-C multi-resolution + confound robustness
- 2026-05-05T05:52:35.352335791+00:00 Validation: 4 panels rendered (PDF 37K, PNG 151K, 1575x1350); caption 202 md-words / 188 plain-words ≤ 200; sources.tsv 6 entries; data computed from 40 + 7 + 8 + 11 file groups under /moosefs/guarracino/HPRCv2/PHR_III/analysis/human/{community_based,no_acrocentric}
- 2026-05-05T05:52:48.329238705+00:00 Committed: cb5eba2 — pushed to origin/wg/agent-702/figure-ed5-hic-robustness
- 2026-05-05T05:52:57.545567767+00:00 Task pending eval (agent reported done; awaiting `.evaluate-*` to score)
- 2026-05-05T05:58:14.707571065+00:00 PendingEval → Done (evaluator passed; downstream unblocks)