bog-v2-slide-15

BoG v2 slide 15 concerted evolution thesis closer

Metadata

Statusdone
Assignedagent-773
Agent identityf51439356729d112a6c404803d88015d5b44832c6c584c62b96732b63c2b0c7e
Created2026-05-06T00:34:52.222880395+00:00
Started2026-05-06T00:43:32.554681209+00:00
Completed2026-05-06T00:46:49.922120300+00:00
Tagsbog-slide, bog-this-week, eval-scheduled
Eval score0.92
└ blocking impact0.95
└ completeness0.95
└ constraint fidelity0.70
└ coordination overhead0.95
└ correctness0.95
└ downstream usability0.92
└ efficiency0.85
└ intent fidelity0.87
└ style adherence0.95

Description

SHARED CONTEXT — BoG-this-week slide fanout. Lead author: Erik Garrison. Co-author: Andrea Guarracino. ANCHOR: paper_prep/synthesis/ABSTRACT.md. SUBSTRATE: end-to-end-report/ (Andrea 14-chapter report) + paper_prep/synthesis/CROSSWALK.md. EXISTING V1 DECK: slides/20260204_Subtelomics_overview_EG.summary.md (slide-by-slide ChatGPT extract — 240 lines, easiest entry) + slides/20260204_Subtelomics_overview_EG.pdf. TALK SLOT: 15 min. TOTAL SLIDES: 15. OUTPUT FILE: slides/v2/slide_NN_.md (NN = your slide number, slug short). FILE STRUCTURE (mandatory): ## Title (1 line) / ## Bullets (3-5, conference-style) / ## Primary figure (path if exists OR ggplot2/R generation script for any new annotation overlay; light R/ggplot2 work is OK inside agent worktree, no SBATCH) / ## Speaker notes (~150 words) / ## Time budget (target seconds matching the table) / ## Notes for synthesizer (cross-slide concerns, callbacks, what previous slide sets up). DO NOT modify v1 deck files. DO NOT touch other slide files in slides/v2/. Single output file. Single commit per task: "docs: BoG v2 slide NN — ".

THIS SLIDE: 15 — NEW: Synthesis closer (the title-thesis). SUBSTRATE: end-to-end-report/report/07_integrated.md + 14_pedigree_recombination.md; abstract title "Concerted evolution and unorthodox recombination of human subtelomeres". REQUIRED: NEW slide tying together: methodology (IMPG / 12% ER connectivity from slide 3) → empirical (extended pseudohomology + named clades from slides 4-9) → mechanism (Hi-C + 3D + meiotic bouquet from slides 10-12) → proof (pedigree from slide 13) → biology (DUX4 from slide 14) → THESIS. Optional: causal feedback loop schematic from paper_prep/figures/ed8/. End with one-line: "subtelomeres concertedly evolve through ongoing inter-chromosomal exchange — observable in pedigrees, predicted by 3D, recovered by an implicit pangenome graph across HPRC v2". Time budget: 70s.

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