bog-v2-slide-12 — workgraph

Metadata

Status	done
Assigned	`agent-772`
Agent identity	`3184716484e6f0ea08bb13539daf07686ee79d440505f1fdf2de0357707034c3`
Created	2026-05-06T00:34:51.866920417+00:00
Started	2026-05-06T00:42:51.641915663+00:00
Completed	2026-05-06T00:48:54.168087251+00:00
Tags	`bog-slide`, `bog-this-week`, `eval-scheduled`
Eval score	0.62
└ blocking impact	0.70
└ completeness	0.60
└ constraint fidelity	0.70
└ coordination overhead	0.70
└ correctness	0.55
└ downstream usability	0.60
└ efficiency	0.75
└ intent fidelity	0.65
└ style adherence	0.65

Description

SHARED CONTEXT — BoG-this-week slide fanout. Lead author: Erik Garrison. Co-author: Andrea Guarracino. ANCHOR: paper_prep/synthesis/ABSTRACT.md. SUBSTRATE: end-to-end-report/ (Andrea 14-chapter report) + paper_prep/synthesis/CROSSWALK.md. EXISTING V1 DECK: slides/20260204_Subtelomics_overview_EG.summary.md (slide-by-slide ChatGPT extract — 240 lines, easiest entry) + slides/20260204_Subtelomics_overview_EG.pdf. TALK SLOT: 15 min. TOTAL SLIDES: 15. OUTPUT FILE: slides/v2/slide_NN_.md (NN = your slide number, slug short). FILE STRUCTURE (mandatory): ## Title (1 line) / ## Bullets (3-5, conference-style) / ## Primary figure (path if exists OR ggplot2/R generation script for any new annotation overlay; light R/ggplot2 work is OK inside agent worktree, no SBATCH) / ## Speaker notes (~150 words) / ## Time budget (target seconds matching the table) / ## Notes for synthesizer (cross-slide concerns, callbacks, what previous slide sets up). DO NOT modify v1 deck files. DO NOT touch other slide files in slides/v2/. Single output file. Single commit per task: "docs: BoG v2 slide NN — ".

THIS SLIDE: 12 — NEW: Mouse meiotic Hi-C — zygotene peak (the meiotic-bouquet bridge). SUBSTRATE: end-to-end-report/report/08_mouse.md (259 lines; Zuo 2021 mouse meiotic Hi-C 4 stages). KEY NUMBERS: Mantel ρ across leptotene/zygotene/pachytene/diplotene = 0.687 / 0.718 / 0.683 / 0.577. Per-arm-pair correlation peaks at zygotene ρ=0.715, p=4.4e-55, n=344. Mouse T2T B6 + CAST; 39 p-arm flanks have signal (q-arm zero — telocentric). REQUIRED: NEW slide. THE PITCH: bulk human Hi-C is somatic (LCLs are mitotic) but the recombination we explain is meiotic. Mouse zygotene Hi-C is the only meiotic 3D map available, and the Mantel ρ peaks AT THE BOUQUET STAGE when telomeres cluster at the nuclear envelope. This is the meiotic 3D bridge to the recombination story. Cross-species generality is a bonus. Time budget: 60s.

SHARED CONTEXT — BoG-this-week slide fanout. Lead author: Erik Garrison. Co-author: Andrea Guarracino. ANCHOR: paper_prep/synthesis/ABSTRACT.md. SUBSTRATE: end-to-end-report/ (Andrea 14-chapter report) + paper_prep/synthesis/CROSSWALK.md. EXISTING V1 DECK: slides/20260204_Subtelomics_overview_EG.summary.md (slide-by-slide ChatGPT extract — 240 lines, easiest entry) + slides/20260204_Subtelomics_overview_EG.pdf. TALK SLOT: 15 min. TOTAL SLIDES: 15. OUTPUT FILE: slides/v2/slide_NN_<slug>.md (NN = your slide number, slug short). FILE STRUCTURE (mandatory): ## Title (1 line) / ## Bullets (3-5, conference-style) / ## Primary figure (path if exists OR ggplot2/R generation script for any new annotation overlay; light R/ggplot2 work is OK inside agent worktree, no SBATCH) / ## Speaker notes (~150 words) / ## Time budget (target seconds matching the table) / ## Notes for synthesizer (cross-slide concerns, callbacks, what previous slide sets up). DO NOT modify v1 deck files. DO NOT touch other slide files in slides/v2/. Single output file. Single commit per task: "docs: BoG v2 slide NN — <slug>".

THIS SLIDE: 12 — NEW: Mouse meiotic Hi-C — zygotene peak (the meiotic-bouquet bridge).
SUBSTRATE: end-to-end-report/report/08_mouse.md (259 lines; Zuo 2021 mouse meiotic Hi-C 4 stages).
KEY NUMBERS: Mantel ρ across leptotene/zygotene/pachytene/diplotene = 0.687 / 0.718 / 0.683 / 0.577. Per-arm-pair correlation peaks at zygotene ρ=0.715, p=4.4e-55, n=344. Mouse T2T B6 + CAST; 39 p-arm flanks have signal (q-arm zero — telocentric).
REQUIRED: NEW slide. THE PITCH: bulk human Hi-C is somatic (LCLs are mitotic) but the recombination we explain is meiotic. Mouse zygotene Hi-C is the only meiotic 3D map available, and the Mantel ρ peaks AT THE BOUQUET STAGE when telomeres cluster at the nuclear envelope. This is the meiotic 3D bridge to the recombination story. Cross-species generality is a bonus. Time budget: 60s.

Depends on

done .assign-bog-v2-slide-12

Required by

Log

2026-05-06T00:34:51.843064787+00:00 Task paused
2026-05-06T00:37:42.482392383+00:00 Task published
2026-05-06T00:42:51.641919200+00:00 Spawned by coordinator --executor claude --model opus
2026-05-06T00:43:28.350362434+00:00 Starting work — checking prior agent state and substrate
2026-05-06T00:45:47.610791251+00:00 Substrate confirmed: end-to-end-report/report/08_mouse.md, fig4 panel d, sources.tsv. Writing slide now.
2026-05-06T00:47:29.893229711+00:00 Slide draft written: slides/v2/slide_12_mouse_meiotic_zygotene_bouquet.md. Verifying R script syntax.
2026-05-06T00:48:21.774876069+00:00 Committed: 964ce4c — pushed to remote
2026-05-06T00:48:54.168091259+00:00 Task pending eval (agent reported done; awaiting `.evaluate-*` to score)
2026-05-06T00:51:32.422376419+00:00 PendingEval → Done (evaluator passed; downstream unblocks)