bog-v2-slide-11

BoG v2 slide 11 single cell 3d gm12878 sperm

Metadata

Statusdone
Assignedagent-770
Agent identity3577bc75d6ed4f1947509aa5c086c91ce7c997c7806dab6bf6affac647452647
Created2026-05-06T00:34:51.754923702+00:00
Started2026-05-06T00:41:33.572873288+00:00
Completed2026-05-06T00:45:31.395507769+00:00
Tagsbog-slide, bog-this-week, eval-scheduled
Eval score0.94
└ blocking impact0.95
└ completeness0.95
└ constraint fidelity0.70
└ coordination overhead0.95
└ correctness0.95
└ downstream usability0.93
└ efficiency0.90
└ intent fidelity0.88
└ style adherence0.95

Description

SHARED CONTEXT — BoG-this-week slide fanout. Lead author: Erik Garrison. Co-author: Andrea Guarracino. ANCHOR: paper_prep/synthesis/ABSTRACT.md. SUBSTRATE: end-to-end-report/ (Andrea 14-chapter report) + paper_prep/synthesis/CROSSWALK.md. EXISTING V1 DECK: slides/20260204_Subtelomics_overview_EG.summary.md (slide-by-slide ChatGPT extract — 240 lines, easiest entry) + slides/20260204_Subtelomics_overview_EG.pdf. TALK SLOT: 15 min. TOTAL SLIDES: 15. OUTPUT FILE: slides/v2/slide_NN_.md (NN = your slide number, slug short). FILE STRUCTURE (mandatory): ## Title (1 line) / ## Bullets (3-5, conference-style) / ## Primary figure (path if exists OR ggplot2/R generation script for any new annotation overlay; light R/ggplot2 work is OK inside agent worktree, no SBATCH) / ## Speaker notes (~150 words) / ## Time budget (target seconds matching the table) / ## Notes for synthesizer (cross-slide concerns, callbacks, what previous slide sets up). DO NOT modify v1 deck files. DO NOT touch other slide files in slides/v2/. Single output file. Single commit per task: "docs: BoG v2 slide NN — ".

THIS SLIDE: 11 — NEW: Single-cell 3D (GM12878 Dip-C + sperm). SUBSTRATE: end-to-end-report/report/06_dipc_validation.md (Tan 2018 GM12878 + Xu 2025 sperm). KEY NUMBERS: GM12878 16 cells: 6.9% closer within-community, Wilcoxon p=3.8e-04, Mantel ρ=0.296. Sperm 20 cells (Xu et al 2025): W/B=0.401 (60% closer), Fisher p=3.9e-51. Negative-control "S" pseudo-community of 7 zero-signal arms: 11% farther in GM12878, 40% farther in sperm. REQUIRED: NEW slide. Frame: "single-cell 3D confirms the bulk Hi-C signal — and crucially, IT WORKS IN HAPLOID SPERM". Sperm is the bridge to germline cells (next slide is mouse meiotic). Time budget: 60s.

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