Metadata
| Status | done |
|---|---|
| Assigned | agent-58 |
| Agent identity | 3184716484e6f0ea08bb13539daf07686ee79d440505f1fdf2de0357707034c3 |
| Created | 2026-05-02T02:09:38.350298701+00:00 |
| Started | 2026-05-02T02:10:00.778455474+00:00 |
| Completed | 2026-05-02T02:12:08.956776709+00:00 |
| Tags | landing, science, phr, cnv, eval-scheduled |
| Eval score | 0.83 |
| └ blocking impact | 0.84 |
| └ completeness | 0.81 |
| └ constraint fidelity | 0.85 |
| └ coordination overhead | 0.85 |
| └ correctness | 0.84 |
| └ downstream usability | 0.77 |
| └ efficiency | 0.86 |
| └ intent fidelity | 0.77 |
| └ style adherence | 0.88 |
Description
Read-only research task. Inspect https://ulivo.poietic.life/wg/feeds/phrs-cnv-study/ and infer the scientific question and methods around pseudohomologous regions and copy-number-aware gene enrichment analysis. This is not mainly a generic CNV/subtelomere card; focus on copy-number-aware enrichment, weighted/hypergeometric methodology, validation, mapping, and what the trace shows was done. Keep claims conservative and evidence-bound. Deliver 3-5 crisp findings and 1 ultra-short card copy option. Do not edit files.
Depends on
Required by
Log
- 2026-05-02T02:09:55.129777010+00:00 Lightweight assignment: agent=Default Evaluator (31847164), exec_mode=light, context_scope=task, reason=Default Evaluator is the closest fit for a conservative, evidence-bound read-only synthesis task, with strong prior performance and no need for file edits.
- 2026-05-02T02:10:00.778459822+00:00 Spawned by coordinator --executor codex --model gpt-5.5
- 2026-05-02T02:10:21.222992498+00:00 Starting read-only research synthesis; no repository file edits planned.
- 2026-05-02T02:11:49.983049970+00:00 Research synthesis deliverable: Findings: (1) Scientific question appears to be whether PHR/resolved complex loci from pangenome graph analyses can support copy-number-aware gene enrichment or candidate prioritization, especially for repetitive/paralogous/subtelomeric gene families; do not frame it as generic subtelomere discovery. (2) PHR anchor is Guarracino et al. Nature 2023: HPRC/PGGB all-to-all pangenome analysis of acrocentric chromosomes 13/14/15/21/22 identified pseudo-homologous regions with recombination-like signatures. (3) Feed structure shows a copy-number methods cluster: tool checks, mapping copy number into enrichment parameters, weighted hypergeometric/R phyper investigation, edge-case/performance/statistical validation, robust R code, and integration testing. (4) Gene-family research clusters around OR4F, DUX4, TUBB8/tubulin, and GTP-related candidates suggest the demo use case was candidate gene-family interpretation in complex CNV/PHR-adjacent regions. (5) Evidence supports saying WorkGraph coordinated research, benchmarking, synthesis, and validation planning/prototyping; it does not support claiming new validated CNVs, disease associations, or completed clinical results. Ultra-short card copy: Mapped a PHR-linked genomics question into a copy-number-aware enrichment workflow, with graph tasks for candidate gene-family research, statistical modeling, and validation.
- 2026-05-02T02:11:55.034223336+00:00 Validated against urgent correction: framing centers copy-number-aware gene enrichment around PHRs and weighted/hypergeometric methodology; generic CNV/subtelomere wording avoided.
- 2026-05-02T02:12:08.884205157+00:00 Validated: task-specific criteria met; inspected feed/public-local context, delivered 5 findings plus one card copy option in task log, and made no file edits per read-only constraint.
- 2026-05-02T02:12:08.956788110+00:00 Task pending eval (agent reported done; awaiting `.evaluate-*` to score)
- 2026-05-02T02:12:55.609861515+00:00 PendingEval → Done (evaluator passed; downstream unblocks)