lit-review-topic-04

Lit review topic 04: sex chromosome pseudoautosomal regions

Metadata

Statusabandoned
Agent identity3184716484e6f0ea08bb13539daf07686ee79d440505f1fdf2de0357707034c3
Modelcodex:gpt-5.5
Created2026-05-06T01:43:32.880995819+00:00
Tagslit-review, eval-scheduled
Failure reasonoriginally corrupted description; superseded by topic-04-2

Description

SHARED CONTEXT — Lit review fanout for the canonical Nature-format abstract (paper_prep/synthesis/ABSTRACT_nature.md, written by upstream task; falls back to ABSTRACT_BoG.md if Nature version not yet committed in your worktree). The deck/talk substrate is slides/v2/SLIDES_v2_PLAN.md + paper_prep/synthesis/CROSSWALK.md + end-to-end-report/. The author needs a chronologically structured, claim-anchored review per topic that pulls the field together so he can speak confidently in talk, Q&A, and during manuscript writing. OUTPUT FILES: paper_prep/lit_review/topic_NN_.md (1500-3000 words, chronological narrative tying each era`s key findings to claims C1-C8 of the abstract — be honest about which claims a reference supports vs only tangentially relates to) AND paper_prep/lit_review/topic_NN_.bib (BibTeX entries for new references this review introduces; do NOT duplicate entries already in paper_prep/synthesis/REFERENCES.bib — check first). USE WebSearch / WebFetch tools to find recent papers; combine with seed references provided per topic. SCOPE 10-30 references per topic (more for foundational topics, fewer for narrow ones). DO NOT write the manuscript itself; do NOT modify any other lit_review file; single commit per task: "docs: lit review topic NN — ".

THIS TOPIC (04): Sex chromosome PAR1, PAR2, X-added region (XAR), X-transposed region (XTR). PAR1 has obligate crossover; PAR2 is shorter and has more limited recombination. The molecular biology, evolution, and obligate-recombination function. How the abstracts 'recombination via nuclear-envelope-proximity' hypothesis. Mouse meiotic Hi-C (Patel/Zuo) showing zygotene-specific telomere clustering. Connection to subtelomere ectopic exchange.

TIME RANGE: 1900s (Bouquet observation by Eisen) - present.

SEED REFERENCES: Zickler & Kleckner 2015; Hiraoka 2009; Patel/Zuo mouse meiotic. Find ~15-25 more on telomere bouquet, LINC complex, telomere-NE tethering, meiotic chromosome organization.

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