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deep-research-gtp

Deep research: GTP binding / GPCR signaling genes in PHRs

Metadata

Statusdone
Assignedagent-452
Agent identity3184716484e6f0ea08bb13539daf07686ee79d440505f1fdf2de0357707034c3
Created2026-04-02T03:36:04.736897566+00:00
Started2026-04-02T03:36:47.240621470+00:00
Completed2026-04-02T03:42:03.564261476+00:00
Tagsresearch,deep,fan-out, eval-scheduled
Eval score0.93
└ blocking impact0.95
└ completeness0.92
└ coordination overhead0.95
└ correctness0.95
└ downstream usability0.95
└ efficiency0.95
└ intent fidelity0.96
└ style adherence0.94

Description

Goal

Deep literature research on the GTP binding/GTPase/GPCR signaling genes enriched in PHRs — 309-fold enrichment in copy-aware analysis.

Questions

  1. Which genes drive this signal? The comparison CSV says GTPBP6 and IQSEC3 plus the OR genes (which are GPCRs). Clarify exactly which gene families contribute.
  2. GTPBP6: GTP Binding Protein 6. What does it do? It's in PAR1 (chrXp/chrYp). Is it well-characterized? Disease associations?
  3. IQSEC3: IQ motif and Sec7 domain-containing protein 3. It's a GEF (guanine nucleotide exchange factor) for ARF GTPases. What does it do? Where is it expressed? We found 16 copies on 16 p-arms.
  4. Is the GTP binding enrichment just ORs? OR genes are GPCRs which signal through G proteins. Is the GTP binding enrichment simply a parent term of the olfactory receptor signal, or are GTPBP6/IQSEC3 adding an independent signal?
  5. IQSEC3 in the brain: IQSEC3 is known as a postsynaptic density protein in GABAergic synapses. Is the 16-copy subtelomeric distribution known in the neuroscience literature?
  6. Copy number significance: Does having 16 copies of IQSEC3 across chromosome arms have any known functional consequence?

Output

Log detailed research. Save as deep_research_gtp_binding.md.

Validation

  • Each gene family is individually characterized
  • Whether GTP signal is independent from OR signal is clarified
  • IQSEC3 neuroscience context is addressed

Depends on

Required by

Log